Transient Potential Receptor (TRP) channels function to mediate multiple sensory functions such as vision, nociception, taste transduction, temperature sensation and pheromone signaling. Such channels in mammals serve as nonselective cation influx channels expressed in many tissues on mammalian cell surface membranes and these act to regulate the flow of Ca++, Mg++, and Mn++ into cells. TRP channels also serve as interactive responses for sensory phytochemical compounds (such as spices) to activate and open TRP channels for cation influx. Serving as interactive partners for TRPs, antimicrobial-like (AMPL) peptides constitute a unique class of naturally occurring agents that serve as the first line of defense of the mammalian innate (immediate) immune response system. The AMPLs provide protection and defense against microorganisms that gain entrance into the body; such microbes can include bacteria, parasites, and fungi. The present report reviews the interactive activities between the TRPs and the AMPLs that both aid and benefit physiological interactions in the course of cancer treatments, therapies, and chemotherapeutic procedures. Such therapeutic interactions between TRPs and AMPLs lead to propose the concept that tumor growth suppressive activities, exemplified by the interaction between TRPs and AMPs, can and do occur and could be effacious in treating various types of cancers such as gastrointestinal, sexual/reproductive, and urogenital malignancies.